Initial vaccination must be done according to management and breeding programs on a specific farm. The following schedule can be changed to fit specific farm needs.

Animals that have not been immunised before

Time of administration Essential vaccines Dose and route
6 – 8 weeks before the breeding season Rift Valley fever (inactivated) 2 mℓ subcutaneously
6 – 8 weeks before the breeding season RVF (live vaccine) OR Clone 13 1 mℓ subcutaneously
7 – 14 days of age Paratyphoid (1st inject) (live or inactivated vaccine) 5 mℓ subcutaneously (live or inact)
10 mℓ subcutaneously (inact for cows)
7 – 14 days of age Heartwater blood (endemic areas) (0 – 21 days of age) 3 mℓ intraveneously
3 – 8 weeks of age Paratyphoid (2nd inject) (Inactivated vaccine at 3 weeks of age) 5 mℓ subcutaneously (live or inact)
10 mℓ subcutaneously (inact for cows)
4 months of age Contagious abortion S19 (heifers at 4 to 8 months) 2 mℓ subcutaneously
4 months of age **Gall sickness (3 – 9 months) endemic areas 1 mℓ intramuscularly
5 – 6 months of age or at weaning Rift Valley fever (inactivated vaccine) 2 mℓ subcutaneously
5 – 6 months of age or at weaning Clone 13 1 mℓ subcutaneously
5 – 6 months of age or at weaning Rift Valley live 1 mℓ subcutaneously
5 – 6 months of age or at weaning Botulism/Blackquarter (2nd inject) 5 mℓ subcutaneously
5 – 6 months of age or at weaning Botulism/Gasgangrene (2nd inject) 5 mℓ subcutaneously
5 – 6 months of age or at weaning Doublesure 2 mℓ subcutaneously
5 – 6 months of age or at weaning Lumpy-skin disease 2 mℓ subcutaneously
Late winter, Early spring (Aug – Sept) B Phemeral (Dairy cattle) 2 mℓ subcutaneously

Yearly or six monthly booster injections can be given. The following table is a practical example that can be changed to fit the local farming conditions.

Sustained immunisation programme for adult cattle

Time of administration Essential vaccines Dose and route
Late winter, Early spring (Aug – Sept) B Phemeral (Three-day stiff sickness) 2 mℓ subcutaneously
Late winter, Early spring (Aug – Sept) Lumpy skin disease 2 mℓ subcutaneously
Late winter, Early spring (Aug – Sept) Rift Valley fever (Inactivated vaccine) 2 mℓ subcutaneously
Late winter, Early spring (Aug – Sept) Clone 13 1 mℓ subcutaneously
Late winter, Early spring (Aug – Sept) Rift Valley (Live) 1 mℓ subcutaneously
Autumn or Early winter (April – June) Blackquarter/Botulism 5 mℓ subcutaneously
Autumn or Early winter (April – June) Gasgangrene 5 mℓ subcutaneously
Autumn or Early winter (April – June) Anthrax 2 mℓ subcutaneously
Autumn or Early winter (April – June) Botulism – (if combinations were not used) 2 mℓ subcutaneously

Source: Onderstepoort Biological Products